OLIVENOL™ livin' Malaysia

Discovering How OLIVENOL livin’ Works

Doctors who are using OLIVENOL livin’ as adjuvant and adjunctive therapy continues to observe good results in their patients. Inevitably, they share this with their peers.

In the last 6 weeks, we have been inundated with enquiries from more doctors who are skeptically fascinated but yet curious how natural molecules from olives is able to deliver results on indications that is difficult to treat with conventional drug therapy. So we receive many request from doctors to explain how OLIVENOL livin’ actually works.

We have compiled a library of published research on olive polyphenol and hydroxytyrosol (HT) that is conducted around the world. We share this with doctors and pharmacists in our network. With these information, the professionals are able to understand how the anti-inflammatory properties of OLIVENOL livin’ is activated. Understanding this gives them confidence to introduce the product in their case management of chronic indications such as eczema, psoriasis and arthritis.

We believe the general public may also benefit if they understand the science behind the product they consume. Therefore, we shall be making available relevant publications on this blog.

The first article we want to share with you is a recent paper explaining how Hydroxytyrosol (HT) inhibits pro-inflammatory cytokines.

Hydroxytyrosol, the active ingredient in OLIVENOL livin'

Abstract

Hydroxytyrosol (HT), isolated from extra-virgin olive oil, possesses a marked antioxidant activity and is a good radical scavenger. In this study, our aim was to examine the anti-inflammatory mechanism of HT through measuring the inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) expression, TNF-α formation, and nitric oxide (NO) release in lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells. Results showed that HT remarkably suppressed the LPS (1 μg/ml) induction of NO release. It also significantly attenuated the LPS-induced transcription of TNF-α, iNOS, and COX-2 in a dose-dependent manner.

Furthermore, it was also found that HT in a concentration-dependent manner inhibited the expression of iNOS and COX-2 in THP-1 cells treated with 1 μg/ml LPS using Western Blot. Taken together, these results suggest that HT exerts anti-inflammatory effects probably through the suppression of COX-2 and iNOS expression.

Xiaomei Zhang, Jun Cao, Laifu Zhong, Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells, Naunyn-Schmied Arch Pharmacol (2009) 379:581–586

The full article is available for download >> HERE <<

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Tags: cytokines, HT, hydroxytyrosol, inflammation, paper, publications, research